ZNF215

Across TCGA patient cohorts, ZNF215 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF215-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Annexin-1, and FoxM1. Each is linked with ZNF215 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF215-to-partner and partner-to-ZNF215 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by ZNF215-low versus ZNF215-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF215→partner) and Y-score (partner→ZNF215) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.904	+2.459	<.001	.020	3	2
SKCM	Annexin-1 →	+0.470	+2.459	.033	.020	3	2
UCEC	FoxM1 →	+0.306	+4.321	.002	<.001	3	2
UCEC	Ku80 →	+0.293	+2.100	.001	.003	3	2
UCEC	ATM →	-0.649	-2.584	<.001	.001	3	2
UCEC	C-Raf →	+0.191	+1.678	<.001	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Acetyl-a-Tubulin-Lys40 by ZNF215 expression — SKCM

Explore this box plot interactively →