ZNF214

Across TCGA pan-cancer cohorts, ZNF214 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZNF214 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZNF214 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF214 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LIHC show a favorable association.

COAD, UCEC, and BLCA are the cancer types where ZNF214 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.211	0.753	<.001	30	view →
UCEC	DFS	Median	All	0.966	0.618	.010	28	view →
BLCA	OS	Median	All	0.187	0.720	.002	15	view →
LUSC	DFS	Median	III,IV	0.079	0.658	<.001	14	view →
LUAD	OS	Median	All	0.238	0.697	.015	6	view →
LIHC	DFS	Median	All	1.000	0.536	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZNF214–COAD (DFS)

Open the COAD breakdown →