ZNF214

Across TCGA patient cohorts, ZNF214 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF214-associated genes across cancer lineages are Caspase-7-cleavedD198, Caspase-8, and 4E-BP1. Each is linked with ZNF214 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF214-to-partner and partner-to-ZNF214 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF214-low versus ZNF214-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF214→partner) and Y-score (partner→ZNF214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.422	+1.736	.040	.007	3	3
UCEC	Caspase-8 →	-0.295	-2.938	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.277	+3.321	.003	.009	3	2
UCEC	C-Raf →	+0.194	+2.938	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.572	+3.584	.003	.002	3	2
UCEC	FoxM1 →	+0.183	+1.736	.041	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by ZNF214 expression — UCEC

Explore this box plot interactively →