ZNF207

Across TCGA pan-cancer cohorts, ZNF207 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZNF207 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF207 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF207 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where ZNF207 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.328	0.889	.014	35	view →
PDAC	DFS	Tertile	All	0.916	0.710	.001	16	view →
LUAD	DFS	Quartile	III,IV	0.944	0.367	.004	13	view →
LSCC	DFS	Quartile	II,III,IV	0.933	0.533	.010	9	view →
UCEC	DFS	Median	All	0.950	0.773	.007	6	view →
GBM	OS	Median	All	0.638	0.409	.034	2	view →
CCRCC	OS	Median	All	0.922	0.765	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZNF207–HNSC (DFS)

Open the HNSC breakdown →