ZNF200

Across TCGA patient cohorts, ZNF200 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF200-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ACC1. Each is linked with ZNF200 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF200-to-partner and partner-to-ZNF200 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ZNF200-low versus ZNF200-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF200→partner) and Y-score (partner→ZNF200) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.102	-3.143	.016	.018	3	1
UCEC	EGFR_pY1068 →	-0.310	-2.906	.003	.001	3	1
UCEC	ACC1 →	+0.316	+3.013	.040	.018	3	1
UCEC	JNK2 →	+0.223	+2.222	.008	.011	3	1
UCEC	MEK1 →	+0.378	+2.584	.014	.010	3	1
UCEC	MSH2 →	-0.240	-2.973	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by ZNF200 expression — UCEC

Explore this box plot interactively →