ZNF20

Across TCGA pan-cancer cohorts, ZNF20 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF20 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF20 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF20 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UVM, HNSC, and LIHC are the cancer types where ZNF20 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.213	0.718	.002	27	view →
HNSC	OS	Median	All	0.198	0.768	.001	12	view →
LIHC	OS	Median	II,III,IV	0.247	0.637	.012	9	view →
UCEC	DFS	Median	All	0.961	0.619	.015	6	view →
SKCM	DFS	Median	II,III,IV	0.192	0.707	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF20–UVM (OS)

Open the UVM breakdown →