ZNF2

Across TCGA pan-cancer cohorts, ZNF2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZNF2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZNF2 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where ZNF2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.992	.005	5	view →
LSCC	Male	All	−0.478	.003	4	view →
HNSC	All	IV	−1.485	<.001	2	view →
LUAD	Male	All	−0.385	.001	2	view →
LSCC	Female	All	+0.120	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 4 lineages.

ZNF2–COAD

Open the COAD breakdown →