ZNF189

Across TCGA pan-cancer cohorts, ZNF189 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF189 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ZNF189 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF189 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

GBM, CCRCC, and LSCC are the cancer types where ZNF189 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.652	0.785	.029	4	view →
CCRCC	DFS	Tertile	All	0.360	1.000	.021	4	view →
LSCC	OS	Tertile	II,III,IV	0.938	0.603	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF189–GBM (DFS)

Open the GBM breakdown →