ZNF189

Across TCGA patient cohorts, ZNF189 mutation is significantly associated with the RNA expression of many other genes, with 4,956 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF189-associated genes across cancer lineages are CCL27, LINC01331, and RNU4ATAC13P. Each is linked with ZNF189 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF189-to-partner and partner-to-ZNF189 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL27 grouped by ZNF189-low versus ZNF189-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF189→partner) and Y-score (partner→ZNF189) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCL27 →	+0.051	+4.578	<.001	.008	3	3
CESC	LINC01331 →	+0.101	+3.760	<.001	.007	3	2
CESC	RNU4ATAC13P →	+0.230	+5.579	<.001	.001	3	2
CESC	MIR4497 →	+0.418	+3.944	.008	.007	3	2
CESC	RNVU1-26 →	+0.703	+3.705	<.001	.008	3	2
UCEC	QDPR →	+0.399	+2.695	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,956 associations by consensus.

CCL27 by ZNF189 expression — HNSC

Explore this box plot interactively →