ZNF189

Across TCGA patient cohorts, ZNF189 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF189-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and eIF4E. Each is linked with ZNF189 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF189-to-partner and partner-to-ZNF189 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZNF189-low versus ZNF189-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF189→partner) and Y-score (partner→ZNF189) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.312	+1.817	.003	.015	3	2
UCEC	EGFR_pY1068 →	-0.253	-1.938	.002	.001	3	1
UCEC	eIF4E →	+0.152	+1.652	.028	.006	3	1
UCEC	eIF4G →	+0.271	+3.321	.008	.009	3	1
UCEC	A-Raf_pS299 →	-0.105	-2.459	.007	.018	3	1
UCEC	FASN →	+0.263	+1.584	.043	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

p62 Lck ligand by ZNF189 expression — UCEC

Explore this box plot interactively →