ZNF189

Across TCGA cell cohorts, ZNF189 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZNF189-associated genes across cancer lineages are PRSS55, OR2D3, and TMEM114. Each is linked with ZNF189 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF189-to-partner and partner-to-ZNF189 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS55 grouped by ZNF189-low versus ZNF189-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF189→partner) and Y-score (partner→ZNF189) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRSS55 →	+0.055	+3.978	<.001	.005	3	2
LUNG_NSCLC_LUAD	OR2D3 →	+0.026	+3.481	<.001	.004	3	2
LUNG_NSCLC_LUSC	TMEM114 →	+0.096	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	KCNK16 →	+0.413	+4.643	.001	.008	3	1
BLOOD_Lymphoma	WFDC10B →	+0.485	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	CCDC60 →	+0.060	+4.714	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PRSS55 by ZNF189 expression — CNS

Explore this box plot interactively →