ZNF185

Across TCGA pan-cancer cohorts, ZNF185 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ZNF185’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF185 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZNF185 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and PDAC are the cancer types where ZNF185 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF185 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.774	<.001	11	view →
CCRCC	Female	All	−0.529	<.001	11	view →
PDAC	Male	All	+0.832	<.001	9	view →
LUAD	All	III,IV	−0.382	<.001	7	view →
LSCC	All	II,III,IV	+0.271	.010	5	view →
OV	All	All	−0.873	.005	2	view →
COAD	All	II,III,IV	+0.140	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ZNF185–HNSC

Open the HNSC breakdown →