ZNF185

Across TCGA patient cohorts, ZNF185 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF185-associated genes across cancer lineages are JNK_pT183_Y185, PCNA, and Tuberin. Each is linked with ZNF185 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF185-to-partner and partner-to-ZNF185 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ZNF185-low versus ZNF185-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF185→partner) and Y-score (partner→ZNF185) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.147	-1.571	.026	.036	3	2
UCEC	PCNA →	+0.210	+2.000	.013	.030	3	2
UCEC	Tuberin →	+0.357	+2.232	<.001	.005	3	2
UCEC	Caspase-8 →	-0.280	-3.169	.004	<.001	3	2
UCEC	53BP1 →	+0.302	+2.321	.024	.033	3	2
UCEC	EGFR_pY1068 →	-0.235	-2.459	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

JNK_pT183_Y185 by ZNF185 expression — UCEC

Explore this box plot interactively →