ZNF18

Across TCGA patient cohorts, ZNF18 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF18-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with ZNF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF18-to-partner and partner-to-ZNF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ZNF18-low versus ZNF18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF18→partner) and Y-score (partner→ZNF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.087	-3.295	.015	.009	3	1
UCEC	eEF2 →	+0.314	+1.700	.014	.042	3	1
UCEC	EGFR_pY1068 →	-0.320	-3.459	<.001	<.001	3	1
UCEC	EGFR →	-0.171	-2.584	.002	.010	3	1
UCEC	eIF4E →	+0.150	+2.222	.048	.010	3	1
UCEC	A-Raf_pS299 →	-0.145	-2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

14-3-3_beta by ZNF18 expression — UCEC

Explore this box plot interactively →