ZNF18

Across TCGA cell cohorts, ZNF18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,007 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF18-associated GO terms across cancer lineages are Regulation of telomere maintenance via telomerase, Negative regulation of telomere maintenance, and Transport along microtubule. Each is linked with ZNF18 in more than 13 cancer types. Because this analysis shows association rather than direction, both ZNF18-to-partner and partner-to-ZNF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomere maintenance via telomerase grouped by ZNF18-low versus ZNF18-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF18→partner) and Y-score (partner→ZNF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of telomere maintenance via telomerase →	+0.072	+0.590	.003	<.001	3	14
LUNG_SCLC	Negative regulation of telomere maintenance →	+0.082	+0.736	<.001	<.001	3	12
OESOPHAGUS	Transport along microtubule →	+0.055	+0.874	.001	<.001	3	11
STOMACH	Programmed cell death in response to reactive oxygen species →	-0.148	-0.856	.002	.009	3	11
OESOPHAGUS	Golgi vesicle transport →	+0.088	+0.775	.003	.005	2	12
KIDNEY	Regulation of telomere capping →	+0.105	+0.651	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,007 associations by consensus.

Regulation of telomere maintenance via telomerase by ZNF18 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →