ZNF18

Across TCGA cell cohorts, ZNF18 mutation is significantly associated with the RNA expression of many other genes, with 444 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF18-associated genes across cancer lineages are TEX50, CCDC134, and DEPDC5. Each is linked with ZNF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF18-to-partner and partner-to-ZNF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX50 grouped by ZNF18-low versus ZNF18-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF18→partner) and Y-score (partner→ZNF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TEX50 →	+0.026	+5.000	<.001	.005	3	1
LARGE_INTESTINE	CCDC134 →	+0.834	+3.364	<.001	.002	3	1
LARGE_INTESTINE	DEPDC5 →	+0.617	+3.169	.001	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.609	+3.451	.001	.002	3	1
LARGE_INTESTINE	JOSD1 →	+0.590	+3.364	.002	.002	3	1
LARGE_INTESTINE	HMGXB4 →	+0.672	+3.389	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 444 associations by consensus.

TEX50 by ZNF18 expression — KIDNEY

Explore this box plot interactively →