ZNF175

Across TCGA pan-cancer cohorts, ZNF175 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF175 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher ZNF175 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF175 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, BLCA, and UCEC are the cancer types where ZNF175 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	III,IV	0.074	0.574	<.001	24	view →
BLCA	OS	Median	III,IV	0.082	0.582	<.001	12	view →
UCEC	DFS	Median	All	0.904	0.624	.021	12	view →
SARC	OS	Median	All	0.029	0.828	<.001	10	view →
LUAD	DFS	Median	All	0.275	0.667	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF175–ESCA (OS)

Open the ESCA breakdown →