ZNF175

Across TCGA pan-cancer cohorts, ZNF175 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF175 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF175 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF175 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PDAC, LSCC, and COAD are the cancer types where ZNF175 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.286	0.466	.003	38	view →
LSCC	DFS	Median	II,III,IV	0.653	0.890	.018	15	view →
COAD	DFS	Median	III,IV	0.897	1.000	.044	6	view →
UCEC	DFS	Median	All	1.000	0.924	.043	6	view →
LUAD	OS	Quartile	II,III,IV	0.457	1.000	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF175–PDAC (OS)

Open the PDAC breakdown →