ZNF175

Across TCGA patient cohorts, ZNF175 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF175-associated genes across cancer lineages are mTOR_pS2448, p62 Lck ligand, and ASNS. Each is linked with ZNF175 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF175-to-partner and partner-to-ZNF175 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZNF175-low versus ZNF175-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF175→partner) and Y-score (partner→ZNF175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.103	-1.415	.026	.010	3	2
UCEC	p62 Lck ligand →	+0.301	+2.097	.002	.003	3	2
UCEC	ASNS →	+0.301	+1.807	.007	.024	3	2
UCEC	Caspase-7-cleavedD198 →	+0.451	+1.785	.014	.007	3	2
UCEC	cIAP →	+0.101	+1.687	.018	.013	3	2
UCEC	14-3-3_beta →	-0.100	-2.880	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

mTOR_pS2448 by ZNF175 expression — UCEC

Explore this box plot interactively →