ZNF174

Across TCGA patient cohorts, ZNF174 mutation is significantly associated with the RNA expression of many other genes, with 1,409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF174-associated genes across cancer lineages are C18orf32, RNU6-170P, and FCGR1A. Each is linked with ZNF174 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF174-to-partner and partner-to-ZNF174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf32 grouped by ZNF174-low versus ZNF174-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF174→partner) and Y-score (partner→ZNF174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C18orf32 →	+0.468	+3.119	<.001	<.001	3	3
HNSC	RNU6-170P →	+0.256	+4.924	<.001	<.001	3	2
UCEC	FCGR1A →	+0.840	+3.627	<.001	.001	3	2
UCEC	SKA1 →	+0.643	+3.346	.003	.005	3	2
UCEC	TEF →	+0.521	+2.415	.001	.003	3	2
UCEC	REEP4 →	+0.567	+3.606	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,409 associations by consensus.

C18orf32 by ZNF174 expression — UCEC

Explore this box plot interactively →