ZNF174

Across TCGA patient cohorts, ZNF174 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF174-associated genes across cancer lineages are p27_pT198, Acetyl-a-Tubulin-Lys40, and MSH2. Each is linked with ZNF174 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF174-to-partner and partner-to-ZNF174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by ZNF174-low versus ZNF174-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF174→partner) and Y-score (partner→ZNF174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.109	+3.169	.023	.019	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.538	+2.000	.019	.032	3	2
UCEC	MSH2 →	-0.304	-3.143	.003	.018	3	2
UCEC	mTOR_pS2448 →	-0.196	-3.302	.003	.010	3	2
UCEC	Annexin-1 →	+0.499	+3.019	.035	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.826	+2.341	.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

p27_pT198 by ZNF174 expression — UCEC

Explore this box plot interactively →