ZNF16

Across TCGA patient cohorts, ZNF16 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF16-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and STAT3_pY705. Each is linked with ZNF16 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF16-to-partner and partner-to-ZNF16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF16-low versus ZNF16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF16→partner) and Y-score (partner→ZNF16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.226	-1.678	.019	.023	3	2
UCEC	INPP4B →	-0.314	-1.807	.011	.025	3	2
UCEC	STAT3_pY705 →	-0.387	-1.678	<.001	.023	3	2
UCEC	VHL →	-0.894	-2.807	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.100	-2.558	.009	.010	3	1
UCEC	FoxM1 →	+0.272	+2.584	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

EGFR_pY1068 by ZNF16 expression — UCEC

Explore this box plot interactively →