ZNF157

Across TCGA patient cohorts, ZNF157 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF157-associated genes across cancer lineages are ACC_pS79, Notch1, and STAT3_pY705. Each is linked with ZNF157 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF157-to-partner and partner-to-ZNF157 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by ZNF157-low versus ZNF157-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF157→partner) and Y-score (partner→ZNF157) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.222	+1.523	.044	.008	3	2
UCEC	Notch1 →	+0.127	+1.820	.004	.014	3	2
UCEC	STAT3_pY705 →	-0.265	-1.280	.001	.049	3	2
UCEC	ATM →	-0.478	-2.308	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.734	+2.058	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.212	-2.636	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ACC_pS79 by ZNF157 expression — UCEC

Explore this box plot interactively →