ZNF148

Across TCGA patient cohorts, ZNF148 mutation is significantly associated with the RNA expression of many other genes, with 3,528 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF148-associated genes across cancer lineages are FANCB, XRCC6, and PGAM5. Each is linked with ZNF148 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF148-to-partner and partner-to-ZNF148 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCB grouped by ZNF148-low versus ZNF148-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF148→partner) and Y-score (partner→ZNF148) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCB →	+0.337	+1.893	<.001	<.001	3	3
UCEC	XRCC6 →	+0.399	+2.539	<.001	<.001	3	3
UCEC	PGAM5 →	+0.471	+1.544	<.001	<.001	3	3
UCEC	SKA1 →	+0.765	+1.898	<.001	<.001	3	3
UCEC	SLBP →	+0.445	+1.555	<.001	<.001	3	3
UCEC	LETM1 →	+0.332	+1.930	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,528 associations by consensus.

FANCB by ZNF148 expression — UCEC

Explore this box plot interactively →