ZNF148

Across TCGA patient cohorts, ZNF148 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF148-associated genes across cancer lineages are c-Jun_pS73, EGFR_pY1068, and FASN. Each is linked with ZNF148 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF148-to-partner and partner-to-ZNF148 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Jun_pS73 grouped by ZNF148-low versus ZNF148-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF148→partner) and Y-score (partner→ZNF148) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Jun_pS73 →	-0.090	-1.752	.045	.011	3	3
UCEC	EGFR_pY1068 →	-0.268	-1.632	<.001	<.001	3	2
UCEC	FASN →	+0.223	+1.447	.044	.002	3	2
UCEC	PCNA →	+0.204	+1.632	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.193	-1.632	<.001	<.001	3	2
UCEC	TFRC →	+0.401	+2.415	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

c-Jun_pS73 by ZNF148 expression — UCEC

Explore this box plot interactively →