ZNF148

Across TCGA cell cohorts, ZNF148 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF148-associated genes across cancer lineages are UCP1, PLA2G12B, and DEFB125. Each is linked with ZNF148 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF148-to-partner and partner-to-ZNF148 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCP1 grouped by ZNF148-low versus ZNF148-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF148→partner) and Y-score (partner→ZNF148) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UCP1 →	+0.307	+3.999	<.001	.005	3	1
BLOOD_Leukemia	PLA2G12B →	+0.034	+3.757	<.001	.009	3	1
BLOOD_Leukemia	DEFB125 →	+0.045	+5.475	<.001	<.001	3	1
BLOOD_Leukemia	OR10Q1 →	+0.021	+4.384	<.001	.006	3	1
BLOOD_Leukemia	OR6C70 →	+0.022	+4.507	<.001	.001	3	1
BLOOD_Leukemia	SLC36A2 →	+0.016	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

UCP1 by ZNF148 expression — BLOOD_Leukemia

Explore this box plot interactively →