ZNF146

Across TCGA pan-cancer cohorts, ZNF146 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF146 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF146 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF146 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where ZNF146 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.720	0.947	.016	14	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.678	.013	11	view →
GBM	OS	Tertile	All	0.680	0.269	.001	9	view →
PDAC	OS	Tertile	All	1.000	0.686	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF146–HNSC (OS)

Open the HNSC breakdown →