ZNF146

Across TCGA patient cohorts, ZNF146 mutation is significantly associated with the RNA expression of many other genes, with 4,328 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF146-associated genes across cancer lineages are RNU6-492P, BPY2DP, and SRP9P1. Each is linked with ZNF146 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF146-to-partner and partner-to-ZNF146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-492P grouped by ZNF146-low versus ZNF146-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF146→partner) and Y-score (partner→ZNF146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	3
STAD	BPY2DP →	+0.304	+5.105	<.001	.008	3	2
UCEC	SRP9P1 →	+0.608	+2.040	.002	.005	3	2
UCEC	HSP90AA6P →	+0.535	+2.934	<.001	<.001	3	2
UCEC	PDCD1 →	+0.909	+3.254	<.001	<.001	3	2
UCEC	CALHM6 →	+0.988	+2.378	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,328 associations by consensus.

RNU6-492P by ZNF146 expression — HNSC

Explore this box plot interactively →