ZNF146

Across TCGA patient cohorts, ZNF146 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF146-associated genes across cancer lineages are GAPDH, TFRC, and ASNS. Each is linked with ZNF146 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF146-to-partner and partner-to-ZNF146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ZNF146-low versus ZNF146-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF146→partner) and Y-score (partner→ZNF146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.590	+2.820	.034	.035	3	2
UCEC	TFRC →	+0.722	+3.807	<.001	<.001	3	2
UCEC	ASNS →	+0.508	+2.392	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.276	-2.415	.001	.003	3	1
UCEC	eIF4E →	+0.243	+2.874	.001	<.001	3	1
UCEC	eIF4G →	+0.218	+1.362	.046	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

GAPDH by ZNF146 expression — COAD

Explore this box plot interactively →