ZNF143

Across TCGA pan-cancer cohorts, ZNF143 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF143 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF143 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF143 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where ZNF143 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.886	0.563	<.001	23	view →
PDAC	DFS	Quartile	II,III,IV	0.585	0.305	.010	10	view →
CCRCC	DFS	Median	All	0.514	0.908	.009	5	view →
LUAD	OS	Tertile	All	1.000	0.821	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF143–LSCC (DFS)

Open the LSCC breakdown →