ZNF143

Across TCGA cell cohorts, ZNF143 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF143-associated genes across cancer lineages are MMP26, C10orf53, and KRTAP4-1. Each is linked with ZNF143 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF143-to-partner and partner-to-ZNF143 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by ZNF143-low versus ZNF143-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF143→partner) and Y-score (partner→ZNF143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMP26 →	+0.033	+3.217	<.001	.006	3	1
LARGE_INTESTINE	C10orf53 →	+0.013	+3.217	<.001	.006	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	FAM25C →	+0.351	+5.209	<.001	.005	3	1
LARGE_INTESTINE	SMIM33 →	+0.820	+3.426	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MMP26 by ZNF143 expression — LARGE_INTESTINE

Explore this box plot interactively →