ZNF142

Across TCGA pan-cancer cohorts, ZNF142 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF142’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF142 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF142 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where ZNF142 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF142 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.061	<.001	11	view →
HNSC	All	III,IV	+0.592	<.001	11	view →
LIHC	Female	II,III,IV	+1.313	<.001	9	view →
KICH	Male	All	−0.988	<.001	8	view →
THCA	All	II,III,IV	−0.556	<.001	8	view →
STAD	Male	II,III,IV	+1.222	<.001	6	view →
CHOL	Female	All	+2.746	<.001	5	view →
KIRP	All	II,III,IV	+0.585	.007	5	view →
READ	All	All	+0.756	<.001	4	view →
KIRC	Female	All	+0.469	.001	4	view →
LUSC	All	All	+0.339	<.001	4	view →
BLCA	Female	III,IV	+0.414	.022	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF142–COAD

Open the COAD breakdown →