ZNF135

Across TCGA pan-cancer cohorts, ZNF135 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZNF135 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher ZNF135 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF135 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THCA, COAD, and BRCA are the cancer types where ZNF135 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.255	0.954	<.001	20	view →
COAD	OS	Median	IV	0.180	0.656	.018	9	view →
BRCA	DFS	Median	All	0.786	0.950	<.001	4	view →
LIHC	DFS	Median	All	0.126	0.534	.003	3	view →
UCEC	DFS	Median	All	0.928	0.621	.043	2	view →
SKCM	OS	Median	All	0.178	0.331	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZNF135–THCA (OS)

Open the THCA breakdown →