ZNF132

Across TCGA patient cohorts, ZNF132 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF132-associated genes across cancer lineages are Notch1, cIAP, and MEK1. Each is linked with ZNF132 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF132-to-partner and partner-to-ZNF132 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF132-low versus ZNF132-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF132→partner) and Y-score (partner→ZNF132) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.151	+1.459	<.001	.012	3	3
SKCM	cIAP →	+0.172	+2.833	.040	.034	3	2
UCEC	MEK1 →	+0.455	+2.321	<.001	<.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.345	+2.824	<.001	.034	3	2
UCEC	eEF2 →	+0.291	+2.222	.012	.009	3	2
UCEC	EGFR_pY1068 →	-0.253	-2.169	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Notch1 by ZNF132 expression — UCEC

Explore this box plot interactively →