ZNF131

Across TCGA patient cohorts, ZNF131 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF131-associated genes across cancer lineages are eEF2, PDCD4, and Caspase-7-cleavedD198. Each is linked with ZNF131 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF131-to-partner and partner-to-ZNF131 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZNF131-low versus ZNF131-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF131→partner) and Y-score (partner→ZNF131) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.310	+1.874	.018	.049	3	2
UCEC	PDCD4 →	-0.434	-1.502	.012	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.741	+1.827	<.001	.015	3	2
UCEC	14-3-3_beta →	-0.092	-3.432	.012	.005	3	1
UCEC	EGFR_pY1068 →	-0.233	-1.847	.011	.008	3	1
UCEC	eIF4E →	+0.164	+3.183	.034	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eEF2 by ZNF131 expression — UCEC

Explore this box plot interactively →