Across TCGA pan-cancer cohorts, ZNF121 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF121 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF121 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZNF121 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, UCEC, and HNSC are the cancer types where ZNF121 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.951	0.577	.007	10	view →
UCEC	DFS	Quartile	All	0.886	1.000	.046	2	view →
HNSC	OS	Median	III,IV	0.551	0.864	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZNF121 tumor-vs-normal RNA expression · all ZNF121 data types