Across TCGA patient cohorts, ZNF121 mutation is significantly associated with the RNA expression of many other genes, with 2,055 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF121-associated genes across cancer lineages are CENPU, CENPN, and DDIT3. Each is linked with ZNF121 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF121-to-partner and partner-to-ZNF121 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF121→partner) and Y-score (partner→ZNF121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.635	+1.958	.002	.003	3	3
UCEC	CENPN →	+0.691	+3.928	<.001	<.001	3	3
UCEC	DDIT3 →	+0.638	+2.243	<.001	.005	3	3
UCEC	UIMC1 →	+0.446	+3.056	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.734	+3.023	<.001	<.001	3	3
BRCA	FAM74A6 →	+0.025	+6.324	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,055 associations by consensus.

Exploration

ZNF121 survival (RNA) · tumor vs normal (RNA) · all ZNF121 data types