Across TCGA patient cohorts, ZNF121 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF121-associated genes across cancer lineages are EGFR_pY1068, MEK1, and TFRC. Each is linked with ZNF121 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF121-to-partner and partner-to-ZNF121 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF121→partner) and Y-score (partner→ZNF121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.281	-2.502	.004	.002	3	2
UCEC	MEK1 →	+0.505	+3.906	<.001	<.001	3	2
UCEC	TFRC →	+0.522	+2.000	.012	.010	3	2
UCEC	Tuberin →	+0.327	+2.000	.001	.010	3	2
UCEC	Cyclin-B1 →	+0.509	+2.000	.021	.010	3	2
UCEC	eEF2 →	+0.442	+3.321	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

ZNF121 survival (RNA) · tumor vs normal (RNA) · all ZNF121 data types