ZNF12

Across TCGA patient cohorts, ZNF12 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF12-associated genes across cancer lineages are MSH2, ASNS, and ATM. Each is linked with ZNF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF12-to-partner and partner-to-ZNF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ZNF12-low versus ZNF12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF12→partner) and Y-score (partner→ZNF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.185	-1.674	.016	.040	3	2
UCEC	ASNS →	+0.343	+1.321	.004	.029	3	2
UCEC	ATM →	-0.454	-1.584	.002	.009	3	2
UCEC	14-3-3_beta →	-0.111	-2.780	<.001	.003	3	1
UCEC	EGFR →	-0.192	-2.196	<.001	.009	3	1
UCEC	ERK2 →	+0.170	+1.321	.008	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MSH2 by ZNF12 expression — UCEC

Explore this box plot interactively →