ZNF117

Across TCGA pan-cancer cohorts, ZNF117 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated ZNF117 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF117 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF117 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

KIRC, UCEC, and LUSC are the cancer types where ZNF117 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.054	0.881	<.001	48	view →
UCEC	DFS	Median	All	0.953	0.623	.004	36	view →
LUSC	OS	Median	All	0.031	0.762	<.001	24	view →
STAD	DFS	Median	All	0.149	0.710	<.001	15	view →
COAD	OS	Median	III,IV	0.157	0.791	.001	12	view →
ESCA	DFS	Median	III,IV	0.100	0.442	.003	9	view →
OV	OS	Median	All	0.277	0.690	.013	6	view →
SKCM	DFS	Median	II,III,IV	1.000	0.680	.015	4	view →
LGG	DFS	Median	All	0.225	0.728	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ZNF117–KIRC (OS)

Open the KIRC breakdown →