ZNF106

Across TCGA patient cohorts, ZNF106 mutation is significantly associated with the RNA expression of many other genes, with 4,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF106-associated genes across cancer lineages are TTL, NUSAP1, and SLC25A4. Each is linked with ZNF106 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF106-to-partner and partner-to-ZNF106 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTL grouped by ZNF106-low versus ZNF106-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF106→partner) and Y-score (partner→ZNF106) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TTL →	+0.483	+3.727	<.001	<.001	3	3
UCEC	NUSAP1 →	+0.780	+2.237	<.001	<.001	3	3
COAD	SLC25A4 →	+0.482	+3.183	.001	.009	3	3
UCEC	SKA1 →	+0.800	+2.247	<.001	<.001	3	3
COAD	PDK3 →	+0.504	+3.375	.004	.004	3	3
UCEC	C1QBP →	+0.549	+2.566	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,586 associations by consensus.

TTL by ZNF106 expression — COAD

Explore this box plot interactively →