ZNF106

Across TCGA patient cohorts, ZNF106 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF106-associated genes across cancer lineages are ATM, Cyclin-E2, and Caspase-7-cleavedD198. Each is linked with ZNF106 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF106-to-partner and partner-to-ZNF106 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF106-low versus ZNF106-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF106→partner) and Y-score (partner→ZNF106) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.629	-2.378	<.001	<.001	3	4
COAD	Cyclin-E2 →	+0.236	+2.195	.024	.032	3	4
COAD	Caspase-7-cleavedD198 →	+0.753	+2.824	.034	.034	3	3
UCEC	4E-BP1 →	+0.460	+3.247	<.001	<.001	3	3
UCEC	EGFR_pY1173 →	+0.053	+1.550	.038	.004	3	3
UCEC	Smad3 →	+0.115	+1.765	.016	.013	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ATM by ZNF106 expression — UCEC

Explore this box plot interactively →