ZNF101

Across TCGA patient cohorts, ZNF101 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF101-associated genes across cancer lineages are mTOR_pS2448, Caspase-8, and eIF4E. Each is linked with ZNF101 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF101-to-partner and partner-to-ZNF101 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZNF101-low versus ZNF101-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF101→partner) and Y-score (partner→ZNF101) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.145	-3.565	.013	.002	3	2
UCEC	Caspase-8 →	-0.292	-3.673	.003	.001	3	2
UCEC	eIF4E →	+0.193	+2.502	.019	.002	3	1
UCEC	MEK1 →	+0.502	+4.247	<.001	<.001	3	1
UCEC	Notch1 →	+0.205	+2.000	<.001	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.508	-2.115	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

mTOR_pS2448 by ZNF101 expression — UCEC

Explore this box plot interactively →