ZMYND11

Across TCGA patient cohorts, ZMYND11 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMYND11-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and eIF4E. Each is linked with ZMYND11 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZMYND11-to-partner and partner-to-ZMYND11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZMYND11-low versus ZMYND11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMYND11→partner) and Y-score (partner→ZMYND11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.642	+2.341	.001	.003	3	3
UCEC	EGFR_pY1068 →	-0.270	-2.662	.001	<.001	3	2
UCEC	eIF4E →	+0.141	+1.807	.043	.025	3	2
UCEC	mTOR_pS2448 →	-0.103	-1.392	.035	.019	3	2
UCEC	Notch1 →	+0.102	+1.710	.027	.025	3	2
UCEC	p27_pT157 →	-0.057	-2.048	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by ZMYND11 expression — UCEC

Explore this box plot interactively →