ZMYM6

Across TCGA pan-cancer cohorts, ZMYM6 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ZMYM6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZMYM6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZMYM6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where ZMYM6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZMYM6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.379	<.001	11	view →
THCA	Male	All	−0.338	<.001	9	view →
LIHC	Female	II,III,IV	+0.466	<.001	8	view →
CHOL	All	All	+1.064	<.001	5	view →
KICH	All	All	−0.506	<.001	5	view →
UCEC	All	All	−0.304	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ZMYM6–HNSC

Open the HNSC breakdown →