ZMYM5

Across TCGA patient cohorts, ZMYM5 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMYM5-associated genes across cancer lineages are Rad50, ASNS, and ATM. Each is linked with ZMYM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMYM5-to-partner and partner-to-ZMYM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ZMYM5-low versus ZMYM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMYM5→partner) and Y-score (partner→ZMYM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.181	-1.736	.031	.007	3	2
UCEC	ASNS →	+0.533	+2.502	<.001	.001	3	2
UCEC	ATM →	-0.392	-2.308	.012	.033	3	2
UCEC	EGFR_pY1068 →	-0.316	-2.459	<.001	<.001	3	1
UCEC	eIF4E →	+0.198	+2.938	.006	<.001	3	1
UCEC	eIF4G →	+0.282	+2.584	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Rad50 by ZMYM5 expression — UCEC

Explore this box plot interactively →