ZMYM4

Across TCGA patient cohorts, ZMYM4 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMYM4-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with ZMYM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZMYM4-to-partner and partner-to-ZMYM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZMYM4-low versus ZMYM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMYM4→partner) and Y-score (partner→ZMYM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.118	-1.717	.005	.006	3	3
UCEC	Caspase-7-cleavedD198 →	+0.507	+1.736	.002	.001	3	3
UCEC	c-Met_pY1235 →	+0.050	+1.469	.018	.006	3	3
BLCA	Rictor_pT1135 →	+0.177	+2.833	.013	.034	3	2
UCEC	EGFR_pY1068 →	-0.304	-2.237	<.001	<.001	3	2
UCEC	FoxM1 →	+0.189	+1.784	.010	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

mTOR_pS2448 by ZMYM4 expression — UCEC

Explore this box plot interactively →