ZMYM2

Across TCGA pan-cancer cohorts, ZMYM2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZMYM2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZMYM2 RNA is repressed in tumor relative to normal tissue. In most cancer types ZMYM2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and COAD are the cancer types where ZMYM2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZMYM2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.457	<.001	8	view →
THCA	All	II,III,IV	−0.580	<.001	8	view →
COAD	Male	All	+0.740	<.001	6	view →
BLCA	Male	All	+0.730	.001	6	view →
CHOL	Male	All	+1.816	<.001	5	view →
LIHC	All	All	+0.385	<.001	5	view →
LUSC	All	All	+0.417	<.001	4	view →
KIRC	Male	III,IV	−0.346	.008	4	view →
BRCA	All	II,III,IV	+0.226	.014	4	view →
READ	All	III,IV	+0.765	.039	2	view →
STAD	All	II,III,IV	+0.529	.019	2	view →
PRAD	All	All	+0.387	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZMYM2–KICH

Open the KICH breakdown →