ZMPSTE24

Across TCGA pan-cancer cohorts, ZMPSTE24 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZMPSTE24 data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZMPSTE24 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZMPSTE24 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, ACC, and BLCA are the cancer types where ZMPSTE24 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.626	.010	26	view →
ACC	OS	Median	All	0.133	0.686	.004	18	view →
BLCA	DFS	Median	III,IV	0.152	0.574	.001	15	view →
BRCA	OS	Median	All	0.110	0.578	.012	15	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZMPSTE24–UCEC (DFS)

Open the UCEC breakdown →