ZMPSTE24

Across TCGA pan-cancer cohorts, ZMPSTE24 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZMPSTE24 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZMPSTE24 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZMPSTE24 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, LSCC, and COAD are the cancer types where ZMPSTE24 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.872	0.676	<.001	52	view →
LSCC	OS	Median	II,III,IV	0.512	0.880	<.001	29	view →
COAD	DFS	Quartile	II,III,IV	1.000	0.910	.042	12	view →
UCEC	DFS	Quartile	All	0.790	1.000	.017	10	view →
GBM	DFS	Quartile	All	0.196	0.525	.024	5	view →
PDAC	DFS	Tertile	III,IV	0.909	0.543	.015	5	view →
LUAD	OS	Quartile	III,IV	1.000	0.245	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZMPSTE24–HNSC (DFS)

Open the HNSC breakdown →